fc receptors การใช้

• Upon activation by cord factor, Mincle binds the Fc receptor FcR? and Syk.
• The effect of glucocorticoids on Fc receptor expression in immune cells is complicated.
• Fc receptors are also found on eosinophils, monocytes, macrophages and platelets in humans.
• They also express receptors to detect and adhere to endothelium and Fc receptors for opsonin.
• This is because Fc receptors bind antibodies attached to cells targeted for destruction by macrophages.
• CD16 has been identified as Fc receptors Fc?RIIIa ( CD16a ) and Fc?RIIIb ( CD16b ).
• The encoded protein may help couple the Fc receptor to the activation of the respiratory burst.
• Fc?RIIB1 and Fc?RIIB2 have an ITIM sequence and are inhibitory Fc receptors; they do not induce phagocytosis.
• Through an immunological response, the body s Fc portion on the antibody through an Fc receptor, CD16.
• The gamma chains are also subunits of other Fc receptors . [ provided by RefSeq, Jul 2008 ].
• The Fc region of this antibody has been engineered to have Fc receptor non-binding ( FNB ) properties.
• IgE primes the IgE-mediated allergic response by binding to Fc receptors found on the surface of mast cells and basophils.
• As well as endocytic PRRs, phagocytes also express opsonin receptors such as Fc receptor and complement receptor 1 ( CR1 ).
• Initial studies involving ?CD3 as a therapy used Fc receptor ( FCR )-binding monoclonal antibodies, which proved to be very efficacious.
• Use of F ( ab') 2 or Fab fragments ensures that the antibodies are binding to the antigen and not Fc receptors.
• The Fc receptors are isotype-specific, which gives greater flexibility to the immune system, invoking only the appropriate immune mechanisms for distinct pathogens.
• IgE's Fab paratope binds to allergic antigen, for example house dust mite particles, while its Fc region binds to Fc receptor ?.
• This allows a single antibody to be used by different types of Fc receptors, expressed on different parts of the immune system.
• Whereas the antibody uses its Fc region to bind to Fc Receptors on leukocytes, TCR is already docked onto the cell membrane.
• Fc receptors specifically bind to the Fc region of immunoglobulins ( Igs ) to mediate the unique functions of each Ig class.